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Wednesday, May 16, 2012
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Research shows how cells eliminates oxidized proteins
The presence of oxygen and the development of aerobic metabolism on Earth allowed living beings to take advantage of the energy in foods in a much more efficient manner. This evolutionary achievement, however, came at a price: it left cells vulnerable to the effects of oxidizing substances.
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These byproducts of aerobic respiration interact with proteins, lipids, carbohydrates and nucleic acids, disrupting the functions of these macromolecules. This process can lead to cell death, and in more complex organisms such as humans, it is thought to be one basis for diseases like cancer, arthritis, atherosclerosis, Parkinson’s and Alzheimer’s.
Fortunately, most organisms have developed mechanisms to protect themselves against damage from oxidation. One such mechanism was recently discovered by Brazilian researchers and was featured on the cover of Antioxidants & Redox Signaling, one of the most prominent journals in the field.
The study, financed by FAPESP under its Regular Research Support program and coordinated by Marilene Demasi at the Instituto Butantan’s Biochemistry and Biophysics Laboratory, revealed the strategy used by the yeast Saccharomyces cerevisiae to accelerate the breakdown of oxidized proteins.
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Brazilian researchers develop new polymeric material
Substituting traditional plastic bags for biodegradable polymers is once again fueling discussion about the need to diminish the impact of discarding this type of material in the environment. This switch, however, is hampered by the high costs of a few types of polymers that are degraded in just a few years by the action of natural microorganisms and agents (biodegradable); in contrast, the decomposition of conventional polymers takes centuries.
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More value given to scientific reporting
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Tel: (+55) 11 3838 4000 Fax: (+55) 11 3838 4117 - agencia@fapesp.br
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